Drug Discovery
ILS bioservices provide international quality services for taking your molecules from concept to in-vitro experimental success using High-Throughput Screening, Proteomics, ADMET, Expression profiling, Stability studies, Solubility analysis, Animal free testing, Experimental design and Quality reporting and Digital documentation of total project activities on a proprietary LIMS platform for accountability and transparency.
Our Regular Services include:
- Help in building small molecule repository- general repository and target specific molecule repositories
- SAR studies and initial pharmacodynamics analysis
- High throughput screening for desired pathways/disease indication/ bioactivity
- Customized discovery systems using mammalian, yeast and bacterial systems and multiple promoter-reporter combinations
- Co-culture platforms for microbial pathogenesis tests
- Design and development of Assay systems for sub-genomic RNA interference (antiviral drug discovery)
- FRET systems for Biomolecular interactions
- Octet RED platforms for rapid protein interaction studies
- Expression, characterization and Protein modification studies
- GPCR and Kinase profiling
- Antibody arrays
- Gene and protein Transfection services
Our Customized Discovery Platforms
Cosmeceutical Discovery using Microarray based Expression profiling systems
Optimized ANIMAL FREE RESEARCH SYSTEM for cosmeceutical discovery and validation
Specific Microarray based design and development of Animal free Research systems for multifaceted testing of cosmetological products can be accomplished under this program. Briefly, novel cell lines representing epithelial keratinocytes, ectocervical vaginal cells, buccal cavity cells, melanocytes and their corresponding tumor derived cell populations. Using a proprietary technology, stable cell lines are developed and their wild type (control) profile is characterized using advanced genomic tools. Panels thus created will be specific for hypersensitivity reactions, toxicity responding genes, cellular apoptosis genes, aging and senescence pathways related genes and metabolite converting enzyme panels, cytochrome p450 family members etc. These panels are used as reference standards for customized research programs for identifying Cosmeceutical molecules with regards to their activity and toxicity. Additionally, these customized chips will enable the researcher to resolve the time dependent responses of Cosmeceutical and therapeutic molecules.
Time resolved Transcriptional activity Assessment Protocol
Rapid & Quantitative Genomic Assay for Microbial Detection
Avail our comprehensive and innovative genomic method for identifying time dependent amplification of detrimental microbial pathogens or microbial cross contaminants in food, meat and marine products.
It has been well established that emerging economic threats associated with the safety of food and edible materials are indeed a concern to nations that depend largely on exports from the rest of the world. Added to the complexities is the increasing threats to global food security by engineered or man made threats such as large scale sabotage food or edible materials.
Major food pathogens like multiple species of Clostridium, Listeria, Bacillus, Yersinia, Vibrio, Botulism, Brainerd Diarrhea, Cholera, Shigellosis etc. Specific signature sequence will be used for making specific and customized chip for targeted food products such as Kosher meat, marine food products etc.
